Integrative Cardiovascular Laboratories

The Integrative Core Laboratory's primary mission is to study regulation of cardiovascular functions at the intact animal and organ levels. Our expertise in these areas contribute to the mission of the Consortium for Integrative Cardiovascular Research by providing evidence for the eventual whole animal outcome of the implications derived from the microcirculatory (isolated vessels) and vascular biology (isolated endothelial and vascular smooth muscle cell) studies.

Research Interests

The Integrative Core Laboratory specializes in isolated organ and intact animal preparations to study the eventual cardiovascular outcomes of various systems. We are interested in cardiovascular outcomes in health and disease, and the events which arise from hemorrhagic loss to promote circulatory collapse. Since hormonal, neural, renal, cardiac and renal systems all contribute to cardiovascular control, we specialize in techniques which can be used to identify the contributions of each of these vital systems and identify their eventual outcome in the intact animal.

We use disease models where cardiovascular functions are altered, such as experimental models of hypertension, obesity, insulin resistance, diabetes, and cardiovascular shock. We also specialize in techniques which can accurately examine these processes in awake intact animals.

Investigators

The Integrative Core Laboratory is under the direction of Robert A. Johnson , Professor of Preclinical Sciences.Current staff consists of trainees which can be viewed here.

Location and Contact Information

The Integrative Core Laboratory is located at William Carey